• Dynamical Network Biology

    Understanding the dynamics of complex biological and biochemical networks.

    Model 1
  • Host-pathogen Interactions

    Dynamics of Host-Influenza and -HIV interaction networks

    Model 2
  • In Silico Drug Therapy

    Using computational models to predict new drug targets for drug re-purposing and combinatorial drug therapies.

    Model 2
  • Computational Modeling Technology

    Development of technologies for the construction, simulation, and analysis of large-scale computational models.

    Model 3
  • STEM Education

    Integration of STEM fields in Life Science education through computational modeling.

    Model 2
  • Network Biology
  • Host-pathogen Interactions
  • Host-pathogen Interactions
  • Host-pathogen Interactions
  • Host-pathogen Interactions


Our research focus is three-fold:

1) Better understand the dynamics of molecular and cellular mechanisms in complex networks under healthy as well as diseased conditions; in particular as related to the immune system,

2) Development of technologies to enable more efficient utility of computational systems biology, and

3) Implementation of interactive technologies and computational modeling as a means to improve STEM education.



Abou-Jaoudé W, Traynard P, Monteiro PT, Saez-Rodriguez J, Helikar T, Thieffry D, Chaouiya C. (2016) Cellular Networks: Logics and Dynamics. Frontiers in Genetics.7:94

Puniya B., Allen L., Hochfelder C., Majumder M., Helikar T. (2016) Systems Perturbation Analysis of a Large Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics. Frontiers in Bioengineering and Biotechnology.4:10. doi: 10.3389/fbioe.2016.00010

Helikar T., Cutucache C. E., Herek T., Rogers J. (2015) Integrating interactive computational modeling in biology curricula. PLoS Computational Biology. 11(3): e1004131

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Contact Us

You can find us in the Biochemistry Department located in the Beadle Center.

Beadle Center
1901 Vine St
Lincoln, Nebraska 68503

email: thelikar2@unl.edu
tel: 402-472-3530